effects of thyroid stimulating hormone (tsh) level on clinical pregnancy rate via in vitro fertilization (ivf) procedure

نویسندگان

marziyeh aghahosseini shariati hospital, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

homa asgharifard former resident of shariati hospital, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

ashraf aleyasin shariati hospital, tehran university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

arash tehrani banihashemi department of epidemiology, iran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

چکیده

background :subclinical hypothyroidism may adversely affect in vitro fertilization (ivf) outcomes. however the cutoff of thyroid-stimulating hormone (tsh) for diagnosis and treatment is controversal. the aim of this study was to find the association of clinical pregnancy rate with regard to tsh levels in women undergoing ivf.   methods: a historical cohort study of 816 infertile patients who underwent ivf in 2011 and 2012 was conducted. the study subjects were categorized in two groups according to their baseline tsh level one with 0.5 ≤tsh< 2.5 miu/l and other with 2.5 ≤tsh< 4.5 miu/l. all patients were followed up for 6 weeks after embroyonic transfer. the outcomes of the study were consisted of rates for human chorionic gonadotropin (hcg) and evaluation of their clinical pregnancies.   results: about 60% of the study subjects had serum tsh level < 2.5 miu/l and 40% ≥ 2.5 miu/l. there were no statistically significant differences in age, years of infertility, bmi, baseline fsh and estradiol level of patients and the type of induction protocols between the study groups. the hcg rise was occurred in 30.4% of the subjects with tsh level < 2.5 miu/l versus 26.3% of the subjects with tsh ≥ 2.5 miu/l (p value= 0.2). the clinical pregnancy rates in the group of patients with tsh < 2.5 miu/l and those with ≥ 2.5 miu/l were 27.1% and 23.9% respectively (p value= 0.3).   conclusion: our results were similar to various studies in which reported lack of association between tsh level in the range of 0.5- 4.5 miu/l and ivf outcomes. it seems that lowering the upper limit of normal tsh should be still considered as a scientific debate.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Thyroid Stimulating Hormone (TSH) level on clinical pregnancy rate via In Vitro Fertilization (IVF) procedure

  Background :Subclinical hypothyroidism may adversely affect In Vitro Fertilization (IVF) outcomes. However the cutoff of thyroid-stimulating hormone (TSH) for diagnosis and treatment is controversal. The aim of this study was to find the association of clinical pregnancy rate with regard to TSH levels in women undergoing IVF.   Methods: A historical cohort study of 816 infertile patients who ...

متن کامل

Effects of Thyroid Stimulating Hormone (TSH) level on clinical pregnancy rate via In Vitro Fertilization (IVF) procedure

BACKGROUND Subclinical hypothyroidism may adversely affect In Vitro Fertilization (IVF) outcomes. However the cutoff of thyroid-stimulating hormone (TSH) for diagnosis and treatment is controversal. The aim of this study was to find the association of clinical pregnancy rate with regard to TSH levels in women undergoing IVF. METHODS A historical cohort study of 816 infertile patients who unde...

متن کامل

Correlation of thyroid stimulating hormone (TSH) level with pregnancy outcome in women undergoing in vitro fertilization.

OBJECTIVE The aim of this study was to determine if pregnancy outcome for women undergoing in vitro fertilization is correlated with pre-conception thyroid-stimulating hormone level. STUDY DESIGN We performed a retrospective cohort study of in vitro fertilization cycles in our private practice with an initial positive serum human chorionic gonadotropin level and thyroid-stimulating hormone le...

متن کامل

What is a normal thyroid-stimulating hormone (TSH) level? Effects of stricter TSH thresholds on pregnancy outcomes after in vitro fertilization.

Using a thyroid-stimulating hormone (TSH) cutoff of 2.5 mIU/L or 4.5 mIU/L, no differences in the rates of clinical pregnancy, delivery, or miscarriage were observed in this large, retrospective cohort study of first-cycle IVF patients from 2005 through 2008, after controlling for age. Although lowering the TSH threshold to 2.5 mIU/L would result in a nearly fivefold increase in the number of w...

متن کامل

Investigating low thyroid stimulating hormone (TSH) level.

This series of occasional articles provides an update on the best use of key diagnostic tests in the initial investigation of common or important clinical presentations. The series advisers are Steve Atkin, professor, head of department of academic endocrinology, diabetes, and metabolism, Hull York Medical School; and Eric Kilpatrick, honorary professor, department of clinical biochemistry, Hul...

متن کامل

THYROID FUNCTION TESTS Thyroid Stimulating Hormone (TSH): The thyroid stimulating hormone (TSH) assay measures the concentration of thyroid stimulating hormone in the serum. TSH assays

The thyroid stimulating hormone (TSH) assay measures the concentration of thyroid stimulating hormone in the serum. TSH assays have been classified by "generation" based on the functional sensitivity of the assay, i.e., the lowest concentration at which the assay is able to maintain an inter-assay precision, expressed in terms of percent coefficient of variation (%CV), of 20% or less. Virtually...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۲۸، شماره ۱، صفحات ۲۸۳-۲۸۶

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023